Bio-acne 20 mg cream is a tretinoin cream that not only removes the pimples from the skin but also works to get rid of the atrophic scars that are usually left behind by this acne. The drug is available in a cream formulation. It is packaged in a tube that has 20 g of Bio-Acne cream in it. It consists of tretinoin in its composition which flakes off a thin layer of the area to which it is applied. In this way, it increases the turnover rate of the skin cells.IT also helps to keep the pores of the skin in a clean state. It can also be applied to fight the signs of aging for example wrinkles. It is advised to be used once or twice every dayc after washing the skin. Patients using this cream might experience some side effects which commonly include redness and itching at the site of application. Other products for acne should not be used in combination with Bio-Acne cream. Pregnant and lactating women must also avoid it.
About Lyth Pharma
Hoang Duc Pharmaceuticals & Medical Suppliers Co. Ltd. is the full name of Lyth pharmaceuticals. It is a company that is based in Vietnam. It has been supplying products to the pharmaceutical world since 1999. The company claims to be expanding ever since it was found. It deals in pharmaceutical products, vaccines and different medical devices in particular. It refers itself as one of the pioneers in the pharmaceutical world of Vietnam. The company takes pride in its extensive network of sales and a highly trained staff. Some of the devices it manufactures include urethroscope, endoscopes and some other devices used in percutaneous surgeries. Lyth Pharma claims to have employed 200 staff members for manufacturing of their products. It aims at providing the people with drugs and devices which are efficient, cost- effective and of premium quality. 
Scientific Studies on Isotretinoin
“Suicide, depression, and isotretinoin: Is there a causal link?” is a research study owned by Douglas G. Jacobs et al. In this research, data from other studies and research was compiled and studied to deduce a possible relationship between the use of isotretinoin and development of depression. The effects of isotretinoin produced in a human body were studied. The authors also threw light upon the depressive disorder, its occurrence and effects in human. Finally, a link was tried to get established between the two. However, it was seen that these two factors did not have a connection between them. Substance-Induced Mood Disorder (SIMD) was also studied in this research along with the complexities it brings. The relevance of SIMD with the use of isotretinoin was also studied. At the end of this research, it was concluded that there was no data that was supporting that isotretinoin causes psychiatric changes in the person consuming it. This was because the criterion for the presence of this causality was not met in any of the cases reported in this reference. However, it was suggested that the dermatologists who come across acne patients and suggest isotretinoin to them must be aware of its side effects. They need to maintain a check on these patients for the risk of developing any suicidal tendencies. Also, any mood alteration or symptoms of depression must be observed in the patients who are taking isotretinoin to get rid of their acne problems. 
Harald Gollnick et al studied about the treatment of rosacea in his study named as “Systemic isotretinoin in the treatment of rosacea – doxycycline- and placebo-controlled, randomized clinical study”. Rosacea has been successfully treated by consuming isotretinoin from a long time. This use of isotretinoin is, however, considered to be off-label because there is not enough evidence that can support this claim. The main objective of this study was to establish evidence in favor of isotretinoin in treating rosacea. For this purpose, 573 people were included in a study. All of them were suffering from type 2 or type 3 of rosacea. These people were divided into three groups on the basis of what was given to them during this research. One group received isotretinoin in doses of 0.1, 03 or 0.5 mg per kg of their body weight. The second group was placebo controlled. The third group was given doxycycline in 100 mg potency for initial two weeks after which it was stabilized to 50 mg. Results were recorded. It was seen that 0.3 mg per kg of isotretinoin worked best in these patients. There was 90 percent reduction in lesions seen in patients who were consuming 0.3 mg of isotretinoin. On the contrary, in patients receiving doxycycline, this reduction was up to 83 percent. 24 percent of people receiving 0.3 mg isotretinoin were completely cured while 57 percent of them showed further improvement in rosacea healing. Remission percentage in patients receiving doxycycline was 14 percent while an improvement was seen in 55 percent of them. 0.5 mg per kg of tretinoin was associated with dermatitis facial is more frequently in the patients. It was concluded from this study that 0.3 mg per kg of isotretinoin successfully treats rosacea of both subtypes. It can be used in people instead of oral antibiotics that have been proven to be less efficient according to this study. 
Description and Mechanism of Action of Isotretinoin
Nothing much can be said about the exact mechanism by which isotretinoin works. Isotretinoin is a synthetic derivative of vitamin A. It increases the division and death of the cells of the skin. This causes an increase in cell turnover rate. Keratinization of the skin cells is modified by isotretinoin which consequently decreases the development of comedones in the skin. This process together with an increased turnover rate of cells helps in preventing the formation of acne. Wrinkles and hyper-pigmented skin can also be removed and renewed by the help of isotretinoin owing to this mechanism. 
Bio-Acne Effects for Acne and Scars
It is known that acne causes a blockage of the pores on the face which manifest themselves as small pimples, whiteheads or blackheads. These pimples and blackheads can be unblocked by applying Bio-Acne cream on it. The cream also works to reduce inflammation. It guarantees an acne free skin without leaving behind any scars. Hence, skin becomes smooth, even toned and acne free with the use of this drug. People having stretch marks can also use this cream to get rid of them. Also, by affecting collagen in the skin, it treats wrinkles. Benefits of isotretinoin range to a great extent and can be seen by comparing the before and after results on completion of therapy .
Recommended Doses and Duration of Therapy
Prior to applying Bio-Acne cream, hands must be properly washed. Following this, the diseased area should be washed with a mild cleanser and it should be dried gently. Bio-Acne cream should be applied using the fingertips on the diseased area. The quantity must be equal to the size of a pea and must be applied in the form of a thin layer. It is generally advised to apply it once before going to bed but it can vary according to the doctor’s prescription. Sometimes, waiting for about half an hour is recommended after washing the face in order to apply the cream. The cream is for external use only. It should not be applied to cut skin or skin that is sunburned. 
Side effects and Warnings
Common adverse effects related to the use of Bio-Acne cream are due to its main active ingredient i.e. isotretinoin. Since Bio-Acne is available in the form of a cream, most of the side effects of this drug are related to the skin. Patients using this drug on their skin might notice a color change on their skin. This can be due to an increment or a decrement in the pigment of the skin. At the area of application, redness can be seen. The patient may feel the excessive heat on the concerned area. Skin peeling is also commonly observed at the site of application. Irritation and tingling have also been reported in many cases. The skin becomes more sensitive to sunlight. Some of the more serious and rare side effects of this cream included the development of hives on the skin due to an allergic reaction. The patient might feel difficulty in breathing. His chest may feel tightened. Skin can also become blistered. A general swelling of lips, mouth, face and even tongue can be observed. A doctor should be contacted immediately. 
The patient needs to inform his doctor about the medicines he is currently using prior to getting a prescription for Bio-acne cream. This is because of the tendency of its active ingredient to cross-react with these medicines. Some of these medicines include Phenytoin that is used for treating seizures, steroids like dexamethasone and tetracyclines like doxycycline. Patients using vitamin A supplements are also prone to this cross-reactivity which may result in an exacerbation of side effects of Bio-Acne cream. Breastfeeding mothers should not use this cream and those who plan to breastfeed must wait for a month after they stop using Bio-Acne cream. Patients should also avoid unnecessary exposure to the sun. The doctor also needs to know if the person using this drug has a family history of mental illnesses like depression. Waxing and laser treatments must be avoided. A patient allergic to isotretinoin, vitamin A or any other ingredient of Bio-Acne cream should avoid it for the risk of developing hypersensitivity reactions. 
Bio-acne was found to be completely devoid of customer reviews. Because customer reviews make up for an important factor in deciding in favor or against a particular drug, this situation becomes complex. Also, the absence of reviews is generally regarded as a sign that the drug was not effective enough to make its mark in the online market. A lot of suspicions and doubts arise about such kind of drugs. Bio-Acne is a drug belonging to this type. Nothing definite can be said about it. Hence, it should not be bought and the customers should carefully invest their money on a drug that is safe and comes with a guarantee of working actively to resolve acne problem.
Price, Available Forms, and Dosage
Bio-acne cream is not sold online at any drug store. The drug is manufactured in Vietnam and only sold locally. None of the online drug stores, even those who are working from Vietnam have bio-Acne cream in their stock. This is why no comments can be made referring to the price of this cream. Likewise, the product is also not available for shipping to any other country abroad. In short, this cream is accessible for only the local people of Vietnam and not available to the rest of the world.
Bio-Acne cream consists of isotretinoin in its formula. The dose of isotretinoin must always be maintained between 0.1 mg/kg to 1mg/kg on a daily basis. Since the relevant drug is in cream form, it can be applied twice in the diseased area to gain maximal results. However, a doctor should be consulted in most of the cases before using this drug.
Conclusion and Rating
Bio-Acne cream did not make an impact on me at all. This is because of the same reasons that may apply to any drug which is not available to you. This cream has isotretinoin in it but by now I am definitely convinced that not all products consisting of this agent are effective. This cream is probably one of them since it seriously lacks users’ interest. No reviews have been made by the customers who have used Bio-Acne cream. The drug is not available for purchase on any online drug store. I could not even find a Vietnamese drug store working online who had this cream in its stock. Manufacturer of Bio-Acne is a company about which nothing is known. I do not know whether it is approved by the FDA and I certainly don’t know about the quality of the products it manufactures. Even if I knew about all these facts, I still would not be able to do much as this product is only available to the people of Vietnam. I would give Bio-Acne cream 1 out of 5. The drug needs to be publicized and promoted for people to know about its existence. Also, until this product is not available for people to use internationally, it is not going to make any name for itself.
Bio-Acne Wiki Facts
- Brand: Bio-Acne
- Active Ingredient: Isotretinoin
- Treatment: Acne
- Manufacturer: Lyth Pharma
- Country of Manufacture: Vietnam
- Availability: Vietnam
- Hoang Duc pharmaceuticals & medical supplies CO., LTD. [Internet]. vietnambiz. Available from: http://www.vietnambiz.org/HOANG_DUC_PHARMACEUTICALS_MEDICAL_SUPPLIES_CO__LTDCO__LTD__354.html
- Jacobs DG, Deutsch NL, Brewer M. Suicide, depression, and isotretinoin: is there a causal link?. Journal of the American Academy of Dermatology. 2001 Nov 30;45(5):S168-75. Available from: http://www.sciencedirect.com/science/article/pii/S0190962201107073
- Gollnick H, Blume‐Peytavi U, Szabó EL, Meyer KG, Hauptmann P, Popp G, Sebastian M, Zwingers T, Willers C, Von Der Weth R. Systemic isotretinoin in the treatment of rosacea–doxycycline‐and placebo‐controlled, randomized clinical study. JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 2010 Jul 1;8(7):505-14. Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1610-0387.2010.07345.x/full
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